A highly sensitive hybrid organic-inorganic sensor for continuous monitoring of hemoglobin

Anand Kumar Tatikonda, Maria Tkachev, Ron Naaman*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Microelectronic-based sensors are ideal for real-time continuous monitoring of health states due to their low cost of production, small size, portability, and ease of integration into electronic systems. However, typically semiconductor-based devices cannot be operated in aqueous solutions, especially in solutions with a low pH. However, in this work we overcame this difficulty and demonstrated the feasibility of a hemoglobin sensing array based on hybrid organic GaAs-based devices, which can remain in biological solutions for more than 24 h. This was achieved by coating devices with a nanometer-thick polymer protective layer with subsequent adsorption of antibodies on its surface. The device is capable of functioning even in harsh physiological fluids, such as urine and bile juice. The surface modification allows a change in electrical potential, created by the interaction, to be efficiently transferred to the surface of the semiconductor device. By utilizing an array configuration, it is possible to obtain high sensitivity and selectivity. (C) 2013 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalBiosensors and Bioelectronics
Volume45
DOIs
Publication statusPublished - 15 Jul 2013
MoE publication typeA1 Journal article-refereed

Keywords

  • Hemoglobin
  • Sensor
  • Urine
  • Array
  • Antibody
  • Semiconductor
  • BIOSENSORS
  • SURFACES
  • PASSIVATION
  • ADSORPTION
  • PREVENTION
  • MECHANISM
  • GAAS
  • CARE

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