A DNA Origami-Based Chiral Plasmonic Sensing Device

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A DNA Origami-Based Chiral Plasmonic Sensing Device. / Kuzyk, Anton; Huang, Yike; Nguyen, Kha; Natarajan, Ashwin.

In: ACS Applied Materials and Interfaces, Vol. 10, No. 51, 26.12.2018, p. 44221-44225.

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@article{94c9c09ec38049328072330ff99dc310,
title = "A DNA Origami-Based Chiral Plasmonic Sensing Device",
abstract = "Accurate and reliable biosensing is crucial for environmental monitoring, food safety, and diagnostics. Spatially reconfigurable DNA origami nanostructures are excellent candidates for the generation of custom sensing probes. Here we present a nanoscale biosensing device that combines the accuracy and precision of the DNA origami nanofabrication technique, unique optical responses of chiral plasmonic assemblies, and high affinity and selectivity of aptamers. This combination enables selective and sensitive detection of targets even in strongly absorbing fluids. We expect that the presented sensing scheme can be adapted to a wide range of analytes and tailored to specific needs.",
keywords = "aptamers, biosensing, chiral plasmonics, DNA origami, gold nanorods",
author = "Anton Kuzyk and Yike Huang and Kha Nguyen and Ashwin Natarajan",
year = "2018",
month = "12",
day = "26",
doi = "10.1021/acsami.8b19153",
language = "English",
volume = "10",
pages = "44221--44225",
journal = "ACS Applied Materials and Interfaces",
issn = "1944-8244",
publisher = "AMERICAN CHEMICAL SOCIETY",
number = "51",

}

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TY - JOUR

T1 - A DNA Origami-Based Chiral Plasmonic Sensing Device

AU - Kuzyk, Anton

AU - Huang, Yike

AU - Nguyen, Kha

AU - Natarajan, Ashwin

PY - 2018/12/26

Y1 - 2018/12/26

N2 - Accurate and reliable biosensing is crucial for environmental monitoring, food safety, and diagnostics. Spatially reconfigurable DNA origami nanostructures are excellent candidates for the generation of custom sensing probes. Here we present a nanoscale biosensing device that combines the accuracy and precision of the DNA origami nanofabrication technique, unique optical responses of chiral plasmonic assemblies, and high affinity and selectivity of aptamers. This combination enables selective and sensitive detection of targets even in strongly absorbing fluids. We expect that the presented sensing scheme can be adapted to a wide range of analytes and tailored to specific needs.

AB - Accurate and reliable biosensing is crucial for environmental monitoring, food safety, and diagnostics. Spatially reconfigurable DNA origami nanostructures are excellent candidates for the generation of custom sensing probes. Here we present a nanoscale biosensing device that combines the accuracy and precision of the DNA origami nanofabrication technique, unique optical responses of chiral plasmonic assemblies, and high affinity and selectivity of aptamers. This combination enables selective and sensitive detection of targets even in strongly absorbing fluids. We expect that the presented sensing scheme can be adapted to a wide range of analytes and tailored to specific needs.

KW - aptamers

KW - biosensing

KW - chiral plasmonics

KW - DNA origami

KW - gold nanorods

U2 - 10.1021/acsami.8b19153

DO - 10.1021/acsami.8b19153

M3 - Article

VL - 10

SP - 44221

EP - 44225

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

SN - 1944-8244

IS - 51

ER -

ID: 30316535