A DNA Origami-Based Chiral Plasmonic Sensing Device

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Accurate and reliable biosensing is crucial for environmental monitoring, food safety, and diagnostics. Spatially reconfigurable DNA origami nanostructures are excellent candidates for the generation of custom sensing probes. Here we present a nanoscale biosensing device that combines the accuracy and precision of the DNA origami nanofabrication technique, unique optical responses of chiral plasmonic assemblies, and high affinity and selectivity of aptamers. This combination enables selective and sensitive detection of targets even in strongly absorbing fluids. We expect that the presented sensing scheme can be adapted to a wide range of analytes and tailored to specific needs.
Original languageEnglish
Pages (from-to)44221-44225
JournalACS Applied Materials and Interfaces
Issue number51
Publication statusPublished - 26 Dec 2018
MoE publication typeA1 Journal article-refereed


  • aptamers
  • biosensing
  • chiral plasmonics
  • DNA origami
  • gold nanorods


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