A comparative study of tough hydrogen bonding dissipating hydrogels made with different network structures

Badri Narayanan Narasimhan, Gerrit Sjoerd Deijs, Sesha Manuguri, Matthew Sheng Hao Ting, M. A.K. Williams, Jenny Malmström

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Hydrogels are excellent soft materials to interface with biological systems. Precise control and tunability of dissipative properties of gels are particularly interesting in tissue engineering applications. In this work, we produced hydrogels with tunable dissipative properties by photopolymerizing a second polymer within a preformed cross-linked hydrogel network of poly(acrylamide). We explored second networks made with different structures and capacity to hydrogen bond with the first network, namely linear poly(acrylic acid) and branched poly(tannic acid). Gels incorporating a second network made with poly(tannic acid) exhibited excellent stiffness (0.35 ± 0.035 MPa) and toughness (1.64 ± 0.26 MJ m-3) compared to the poly(acrylic acid) counterparts. We also demonstrate a strategy to fabricate hydrogels where the dissipation (loss modulus) can be tuned independently from the elasticity (storage modulus) suitable for cell culture applications. We anticipate that this modular design approach for producing hydrogels will have applications in tailored substrates for cell culture studies and in load bearing tissue engineering applications. This journal is

Original languageEnglish
Pages (from-to)2934-2947
Number of pages14
JournalNanoscale Advances
Volume3
Issue number10
DOIs
Publication statusPublished - 21 May 2021
MoE publication typeA1 Journal article-refereed

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