A comparative study of tough hydrogen bonding dissipating hydrogels made with different network structures

Badri Narayanan Narasimhan; Gerrit Sjoerd Deijs; Sesha Manuguri; Matthew Sheng Hao Ting; M. A.K. Williams; Jenny Malmström

doi:10.1039/d1na00103e

A comparative study of tough hydrogen bonding dissipating hydrogels made with different network structures

Badri Narayanan Narasimhan, Gerrit Sjoerd Deijs, Sesha Manuguri, Matthew Sheng Hao Ting, M. A.K. Williams, Jenny Malmström

Not published at Aalto University

Research output: Contribution to journal › Article › Scientific › peer-review

17 Citations (Scopus)

Abstract

Hydrogels are excellent soft materials to interface with biological systems. Precise control and tunability of dissipative properties of gels are particularly interesting in tissue engineering applications. In this work, we produced hydrogels with tunable dissipative properties by photopolymerizing a second polymer within a preformed cross-linked hydrogel network of poly(acrylamide). We explored second networks made with different structures and capacity to hydrogen bond with the first network, namely linear poly(acrylic acid) and branched poly(tannic acid). Gels incorporating a second network made with poly(tannic acid) exhibited excellent stiffness (0.35 ± 0.035 MPa) and toughness (1.64 ± 0.26 MJ m-3) compared to the poly(acrylic acid) counterparts. We also demonstrate a strategy to fabricate hydrogels where the dissipation (loss modulus) can be tuned independently from the elasticity (storage modulus) suitable for cell culture applications. We anticipate that this modular design approach for producing hydrogels will have applications in tailored substrates for cell culture studies and in load bearing tissue engineering applications. This journal is

Original language	English
Pages (from-to)	2934-2947
Number of pages	14
Journal	Nanoscale Advances
Volume	3
Issue number	10
DOIs	https://doi.org/10.1039/d1na00103e
Publication status	Published - 21 May 2021
MoE publication type	A1 Journal article-refereed

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10.1039/d1na00103e

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abstract = "Hydrogels are excellent soft materials to interface with biological systems. Precise control and tunability of dissipative properties of gels are particularly interesting in tissue engineering applications. In this work, we produced hydrogels with tunable dissipative properties by photopolymerizing a second polymer within a preformed cross-linked hydrogel network of poly(acrylamide). We explored second networks made with different structures and capacity to hydrogen bond with the first network, namely linear poly(acrylic acid) and branched poly(tannic acid). Gels incorporating a second network made with poly(tannic acid) exhibited excellent stiffness (0.35 ± 0.035 MPa) and toughness (1.64 ± 0.26 MJ m-3) compared to the poly(acrylic acid) counterparts. We also demonstrate a strategy to fabricate hydrogels where the dissipation (loss modulus) can be tuned independently from the elasticity (storage modulus) suitable for cell culture applications. We anticipate that this modular design approach for producing hydrogels will have applications in tailored substrates for cell culture studies and in load bearing tissue engineering applications. This journal is ",

author = "Narasimhan, {Badri Narayanan} and Deijs, {Gerrit Sjoerd} and Sesha Manuguri and Ting, {Matthew Sheng Hao} and Williams, {M. A.K.} and Jenny Malmstr{\"o}m",

note = "Funding Information: The authors gratefully acknowledge the nancial support by the Marsden Fund Council and the Rutherford Discovery Fellowship, from Government funding, managed by Royal Society Te Ap¯arangi. J. M. acknowledges MacDiarmid institute for Advanced Materials and Nanotechnology for their support of this research. The authors thank Dr Sophia Rodrigues and Dr Josh Workman for the useful discussions. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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AU - Narasimhan, Badri Narayanan

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AU - Ting, Matthew Sheng Hao

AU - Williams, M. A.K.

AU - Malmström, Jenny

N1 - Funding Information: The authors gratefully acknowledge the nancial support by the Marsden Fund Council and the Rutherford Discovery Fellowship, from Government funding, managed by Royal Society Te Ap¯arangi. J. M. acknowledges MacDiarmid institute for Advanced Materials and Nanotechnology for their support of this research. The authors thank Dr Sophia Rodrigues and Dr Josh Workman for the useful discussions. Publisher Copyright: © The Royal Society of Chemistry.

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A comparative study of tough hydrogen bonding dissipating hydrogels made with different network structures

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