A comparative cross‐platform meta‐analysis to identify potential biomarker genes common to endometriosis and recurrent pregnancy loss

Pokhraj Guha, Shubhadeep Roychoudhury*, Sobita Singha, Jogen C. Kalita, Adriana Kolesarova, Qazi Mohammad Sajid Jamal, Niraj Kumar Jha, Dhruv Kumar, Janne Ruokolainen, Kavindra Kumar Kesari

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Endometriosis is characterized by unwanted growth of endometrial tissue in different locations of the female reproductive tract. It may lead to recurrent pregnancy loss, which is one of the worst curses for the reproductive age group of human populations around the world. Thus, there is an urgent need for unveiling any common source of origin of both these diseases and con-nections, if any. Herein, we aimed to identify common potential biomarker genes of these two diseases via in silico approach using meta‐analysis of microarray data. Datasets were selected for the study based on certain exclusion criteria. Those datasets were subjected to comparative meta‐anal-yses for the identification of differentially expressed genes (DEGs), that are common to both diag-noses. The DEGs were then subjected to protein‐protein networking and subsequent functional enrichment analyses for unveiling their role/function in connecting two diseases. From the analyses, 120 DEGs are reported to be significant out of which four genes have been found to be prominent. These include the CTNNB1, HNRNPAB, SNRPF and TWIST2 genes. The significantly enriched pathways based on the above‐mentioned genes are mainly centered on signaling and developmental events. These findings could significantly elucidate the underlying molecular events in endometri-osis‐based recurrent miscarriages.

Original languageEnglish
Article number3349
Number of pages17
JournalApplied Sciences (Switzerland)
Volume11
Issue number8
DOIs
Publication statusPublished - 2 Apr 2021
MoE publication typeA1 Journal article-refereed

Keywords

  • Endometriosis
  • Functional enrichment
  • Meta‐analysis
  • Recurrent pregnancy loss
  • TWIST2 gene

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