45S5 BAG-Ti6Al4V structures: The influence of the design on some of the physical and chemical interactions that drive cellular response

Research output: Contribution to journalArticleScientificpeer-review


  • F. Melo-Fonseca
  • R. Lima
  • M. M. Costa
  • F. Bartolomeu
  • N. Alves
  • A. Miranda
  • M. Gasik
  • F. S. Silva
  • N. A. Silva
  • G. Miranda

Research units

  • University of Minho
  • Polytechnic Institute of Leiria
  • ICVS/3B's - PT Government Associate Laboratory


Multi-material Ti6Al4V cellular structures impregnated with 45S5 bioactive glass were designed and produced using Selective Laser Melting (SLM), an additive manufacturing technique, combined with Press and Sintering focusing on load bearing components like hip implants. These structures were designed to combine Ti6Al4V mechanical properties and promote bone ingrowth into the structure as the bioactive material (45S5) is being absorbed and replaced by newly formed bone. The influence of these structures design on some of the physical and chemical aspects that drive cellular response was assessed. Roughness, wettability, bioactive glass quantity and quality on the structures after processing and the pH measured during cell culture (as a consequence of bioactive glass dissolution) were evaluated and correlated with cellular viability, cellular distribution, morphology and proliferation on the surface and inside the structures.


Original languageEnglish
Pages (from-to)95-105
Number of pages11
JournalMaterials and Design
Publication statusPublished - 15 Dec 2018
MoE publication typeA1 Journal article-refereed

    Research areas

  • Bioactive glass 45S5, Multi-material cellular structures, Press and Sintering, Selective Laser Melting, Ti6Al4V

Download statistics

No data available

ID: 27963875