Plasticity and function of the rod/cone gap junction in the retina

Project Details


The remarkable performance of the brain arises partly from the high degree of plasticity in neural circuits. One key feature of plasticity emerges from electrical synapses, gap junctions, that modify the connectivity of neurons and thereby the activity of neural circuits. Understanding the plasticity arising from electrical coupling is crucial to understand the function of neural circuits, and has direct clinical potential. The aim of this collaborative project between the US and Finnish researcher labs is to investigate the role of gap-junctional coupling in the retina - an accessible part of the brain. The key goals are to understand how signals originating from rods navigate through the retina via distinct neural pathways depending on electrical coupling, and the implications of this coupling to visual computations at the levels of the retina and visually guided behavior. The long-standing goal is to establish a US-Finland research hub taking a world-leading role in this field.
Effective start/end date01/01/202231/12/2026

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