Organic Mesocrystals: Formation and controlling of oriented nanoparticles of molecular solids for drug development

Low aqueous solubility of new drugs is a major hurdle in drug development today, which restricts the oral use. Enhancing dissolution of important pharmaceutical solids in the form of mesocrystals is a new strategy. The mesocrystals are intermediate in size between nano and bulk single crystals that are spatially separated and crystallographically oriented self-assembly of nanoparticle substructures, and they exhibit high internal surface i.e. voids/amorphous phase in their structure, enabling better dissolution of drugs. Hence, low aqueous soluble drugs will be prepared in mesocrystal form using different additives and the drug efficacy will be investigated. Furthermore, the formation mechanisms of mesocrystal are not well understood, even though some findings of this topic exist. Therefore, this project will also elucidate the mechanism by forming organic mesocrystals.