Modulation of resource distribution in cells/Tutkimuskulut

Project Details

Description

Engineered microbial cells offer sustainable production alternative for a variety of industrially interesting molecules. Unfortunately, productivities or yields remain often too low for industrial feasibility since the resources are not well distributed between cell growth and production. Therefore the project will develop novel solutions for the modulation of resource distribution in cells to achieve economically attractive sustainable production. Novel computational methods will be developed for designing static and dynamic strategies to modulate resource distribution in cells. Designs will be evaluated in Baker’s yeast, a widely used cell factory. In addition, the cells with modulated resource distribution will be characterized to gain novel knowledge on cellular regulation. The developed methods will offer major solutions to fasten the entering of new cell factories into industrial processes, and provide competitive edge for Finnish industrial biotechnology.

Description

Modulation of resource distribution in cells A variety of industrially interesting molecules have been synthesized from sustainable resources in engineered microbial cells. Yet, achieving industrially feasible production levels requires substantial engineering of cells for diverting resources away from growth to production. However, the complex regulation of cellular resource distribution is limitedly known and compromising growth often leads to low metabolic activity and productivity. The proposed project develops novel methods using metabolic modelling for modulating the cellular resource distributions towards high production. The methods are applicable across organisms and products, but they will be tested in Baker's yeast, a widely used industrial production organism. The developed methods will speed up the entering of new production strains into industrial processes, and provide competitive edge for Finnish industrial biotechnology.
AcronymJouhten Paula AT-kulut
StatusFinished
Effective start/end date01/01/202230/06/2023

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 12 - Responsible Consumption and Production

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