Mapping and tailoring the protein folding compartment for antibody expression in yeast

Project Details


More than 70% of the applied biopharmaceuticals are glycosylated proteins (e.g. antibodies and growth factors) and are therefore produced in mammalian cells. In order to reduce production costs and increase production capacity, many alternative production systems are currently in development. In the project we aim to characterize the capacity of yeast to express properly folded antibodies. We will identify and study the molecular basis for the limitations hampering the use of yeast to produce sufficiently high amounts of antibodies. In the second part of the project we characterize natural antibody producing cells of the immune system and test whether yeast cells can be genetically reprogrammed using the natural antibody producing cells as a blueprint.
Short titleProFold
Effective start/end date01/09/201631/08/2020


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