Algorithmic Designs for Biomolecular Nanostructures (ALBION)

The project develops effective algorithmic methods and novel combinatorial models for the rapidly emerging area of biomolecular nanotechnology. This work aims for the dual goals of: (a) improving our understanding of the computational characteristics of biomolecular self-assembly, and (b) bridging the gap between biomolecular chemistry and computer science, so that computer science techniques can be used to facilitate the creation of increasingly complex biomolecular designs. The project will specifically focus on: (1) algorithmic designs for 3D DNA origami, (2) combinatorial and algorithmic aspects of RNA origami, (3) kinetic models of biomolecular (especially RNA) folding, (4) protein origami structures.