Research output per year
Research output per year
Personal profile
Artistic and research interests
The biochemistry group led by Prof. Silvan Scheller designs energy-relevant biochemical conversions.
The group's research themes focus on biocatalytic transformations that occur in nature but that are currently not possible in classical chemistry. In order to utilize such new metabolisms and enzymes, we first need to understand them in detail. For this reason, his research group carries out fundamental research in microbial physiology and mechanistic enzymology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Methanosarcina acetivorans requires methanol:coenzyme M methyltransferases for ethane formation from ethanol
Somvanshi, T., Tran, M. A., Bao, J. & Scheller, S., 20 Sept 2025, In: Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology. 118, 10, 11 p., 154.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Downloads (Pure) -
Nature AND nurture: enabling formate-dependent growth in Methanosarcina acetivorans
Bao, J., Somvanshi, T., Tian, Y., Laird, M. G., Garcia, P. S., Schöne, C., Rother, M., Borrel, G. & Scheller, S., May 2025, In: FEBS Journal. 292, 9, p. 2251-2271 21 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile3 Citations (Scopus)20 Downloads (Pure) -
Structure of the ATP-driven methyl-coenzyme M reductase activation complex
Ramírez-Amador, F., Paul, S., Kumar, A., Lorent, C., Keller, S., Bohn, S., Nguyen, T., Lometto, S., Vlegels, D., Kahnt, J., Deobald, D., Abendroth, F., Vázquez, O., Hochberg, G., Scheller, S., Stripp, S. T. & Schuller, J. M., 19 Jun 2025, In: Nature. 642, 8068, p. 814-821 8 p., 1091.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile5 Citations (Scopus)15 Downloads (Pure) -
A growth-based screening strategy for engineering the catalytic activity of an oxygen-sensitive formate dehydrogenase
Li, F., Scheller, S. & Lienemann, M., Sept 2024, In: Applied and Environmental Microbiology. 90, 9, 16 p., e01472-24.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Citations (Scopus)30 Downloads (Pure) -
A promoter-RBS library for fine-tuning gene expression in Methanosarcina acetivorans
Zhu, P., Resendiz, M. M., von Ossowski, I. & Scheller, S., Sept 2024, In: Applied and Environmental Microbiology. 90, 9, p. 1-15 15 p., e01092-24.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile4 Citations (Scopus)60 Downloads (Pure)
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Multi-C1: Functional expression of C1-enzymes that evolved for the conversion of multi-carbon substrates
Scheller, S. (Principal investigator), Laird, M. (Project Member), Somvanshi, T. (Project Member) & Sova, K. (Project Member)
01/09/2025 → 31/08/2029
Project: RCF Academy Project
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e-Propane: Proof of concept for a direct CO2-to-propane conversion via genetically engineered microbes, and assessing requirements for its implementation in bioreactors and the economic competitiveness
Scheller, S. (Principal investigator), Salminen, P. (Project Member), Faquir, H. (Project Member), Tian, Y. (Project Member), Oinas, P. (Project Member), Jouhten, P. (Project Member), Tran, M. A. (Project Member), Rehman, S. (Project Member), Telimaa, H. (Project Member), de Dios Mateos, E. (Project Member), Laird, M. (Project Member), Luoma, T. (Project Member) & Mekki, C. (Project Member)
01/04/2024 → 31/03/2026
Project: BF Co-Research
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ExtremoForm: ExtremoForm: Extremophile microorganisms as a source of highly productive enzymes for CO2 reduction to formic acid and other C1 fuels and platform chemicals
Scheller, S. (Principal investigator), Tian, Y. (Project Member), von Ossowski, I. (Project Member), Lamminjoki, L. (Project Member), Mekki, C. (Project Member) & Alameldin, Y. (Project Member)
01/01/2020 → 31/12/2023
Project: RCF Academy Project targeted call
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BioEle: Biochemical interconversion of alkanes to CO2 and electricity
Scheller, S. (Principal investigator), Mohamed, O. (Project Member), Alameldin, Y. (Project Member), Jäger, V. (Project Member), Nguyen, T. (Project Member), Laird, M. (Project Member), Haapanen, M. (Project Member), Molina Resendiz, M. (Project Member), Borowiak, Z. (Project Member), de Dios Mateos, E. (Project Member), Hassinen, J. (Project Member), Adlung, N. (Project Member) & Zhu, P. (Project Member)
01/09/2019 → 31/08/2023
Project: Academy of Finland: Other research funding
Datasets
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Nature and nurture: Enabling formate-dependent growth in Methanosarcina acetivorans
Scheller, S. (Creator), Bao, J. (Creator), Somvanshi, T. (Creator), Tian, Y. (Creator), Laird, M. (Creator), Garcia, P. S. (Creator), Schöne, C. (Creator), Rother, M. (Creator), Borrel, G. (Creator) & Aalto University (Creator), Dryad Digital Repository, 17 Jan 2025
DOI: 10.5061/dryad.931zcrjvd, https://datadryad.org/stash/dataset/doi:10.5061/dryad.931zcrjvd and one more link, https://www.ncbi.nlm.nih.gov/bioproject/1085037 (show fewer)
Dataset
Prizes
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ETH Zurich medal for outstanding doctoral thesis
Scheller, S. (Recipient), 2012
Prize: Award or honor granted for a specific work
Activities
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Talk for high school: Kuninkaantien lukio
Scheller, S. (Participant)
5 May 2021Activity: Participating in or organising an event types › School engagement
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Aalto CHEM Research Day
Scheller, S. (Member), Puurunen, R. (Member), Corona, F. (Member), Jokinen, V. (Member), Bankar, S. (Member) & Vapaavuori, J. (Member)
11 Jun 2021Activity: Participating in or organising an event types › Organization of a workshop, panel, session, tutorial or event
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Eating CO2 and hydrogen
Scheller, S. (Speaker)
19 Feb 2021Activity: Talk or presentation types › Invited academic talk
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Pre-examiner’s Statement: PhD thesis by Benjamin Nji Wandi
Scheller, S. (Examiner)
22 Jun 2021Activity: Academic assessments › Pre-examination of doctoral thesis or acting as opponent to doctoral students or membership of doctoral thesis committee or board
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Converting CO2 to Fuels via Microbes
Scheller, S. (Speaker)
27 Nov 2020Activity: Talk or presentation types › Invited academic talk
Press/Media
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GLOBAL ROUND UP SECTOR WEEKLY: UNIVERSITY NEWSLETTER OF WEEK-ENDED JAN 21, 2024
Halme, M., Sammalkorpi, M., Scheller, S., Miikkulainen, V., Korkeamäki, T. & Jouhten, P.
22/01/2024
1 item of Media coverage
Press/Media: Media appearance
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Researchers at Aalto University Release New Data on Chemicals and Chemistry (Thiol-disulfide Exchange Kinetics and Redox Potential of the Coenzyme M and Coenzyme B Heterodisulfide, an Electron Acceptor Coupled To Energy Conservation In ...)
27/11/2023
1 item of Media coverage
Press/Media: Media appearance
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Research Reports on Escherichia coli from Aalto University Provide New Insights (Comparative analysis of CO2 reduction by soluble Escherichia coli formate dehydrogenase H and its selenocysteine-to-cysteine substitution variant)
02/11/2023
1 item of Media coverage
Press/Media: Media appearance
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Aalto University Reports Findings in Applied and Environmental Microbiology [Application of the Fluorescence-Activating and Absorption-Shifting Tag (FAST) for Flow Cytometry in Methanogenic Archaea]
23/03/2023
1 item of Media coverage
Press/Media: Media appearance
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Doctoral Position for International Students in Microbial Physiology at Aalto University, 2020
07/10/2019
1 item of Media coverage
Press/Media: Media appearance