Ari Koskinen

Personal profile

Artistic and research interests

Professor Ari M.P.Koskinen was born on September 22, 1956 in Finland. He received his M.Sc. (Chem. Eng.) in 1979 (with professor T. Hase, development of the synthesis of alkyl tert-alkyl ethers for anti-knock agents), Licentiate in Technology in 1982 and Doctor of Technology in 1983 (with professor M. Lounasmaa, methodology development on the modified Polonovski reaction for indole alkaloid synthesis), all at the Helsinki University of Technology, Finland. After postdoctoral studies at the University of California, Berkeley (professor Henry Rapoport 1983-85 and 1987-88, total synthesis of anatoxin-a, and conformationally constrained peptidomimetics) he accepted an appointment as a Project Leader in New Drug Development at Orion Corporation – Fermion, Finland (1985-1987). His research group was among the first in Scandinavia to adopt computer aided drug design (QSAR and CoMFA) as well as computerized database handling protocols in new lead identification. Returning to the Academia, he joined the University of Surrey, England, as a lecturer in 1989. He was then appointed as Professor of Chemistry (especially Synthetic Organic Chemistry) at the University of Oulu, Finland in 1992, and transferred to his current position at the Helsinki University of Technology in August, 1999 as Professor of Organic Chemistry (the old Gustav Komppa chair). Prof. Koskinen is a member of the Finnish Academy of Sciences and Letters since 2003. He is the author or co-author of some 190 publications, ten patents and two books.

His research ointerests include the development of novel synthetic methods especially in the field of enantioselective synthesis. A long standing project has centered on the transfer chirality information to new stereocenters on the synthesized molecule utilizing only the existing chiral information in the starting material (internal asymetric induction). The starting materials are selected from readily available, renewable natural compounds (amino acids), and the target compounds are natural products or their analoges with biological significance. Over the years, a number of alkaloids, sphingosine like compounds and imino sugars have been synthesized.

Supervision of post-doc researchers

I have supervised a total of 38 post doctoral researchers during my career as a professor (first at the University of Oulu, and since 2000 at TKK/Aalto). They are:

Bauer, Martin

Bauer, Udo

Chen, Jingshan

Cura, Peter

Edmonds, Michael

Gefflaut, Thierry

Ghiaci, Mehran

Harden, Grahame

Hatam, Mostafa

Kamel, M.S.

Karvinen, Esko

Krische, M.J.

Lajunen, Marja

Munoz, Luis

Nevalainen, Marta

Page, Patrick

Psiorz, Christian

Schwerdtfeger, Jörg

Xia, Zhi-Qiang

Castillo, Joel

Straub, Thomas

Helaja, Juho

Koivisto, Jari

Rajamäki, Suvi

Tois, Jan

Monfray, Jeremy

Stewart, Alan

Bassas, Oriol

Reux, Bastien

Habrant, Damien

Linden, Auri

Chiesa, Katja

Huy, Peter

Venkatesh, K.B.

Tsoukala, Anna

Venkatesh, K.B.

Rembiak, Andreas

Konstantinova, Olga

Education/Academic qualification

Doctor of Science (Technology)

Licentiate of Science (Technology)

Master of Science (Technology)

Keywords

Organic chemistry
Natural products
Asymmetric synthesis

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Research Output

103 Article
40 Working paper
13 Conference contribution
5 Patent
8 More

PROCESS FOR THE PREPARATION OF ARYL SULFONYLPROPENENITRILES BY PHOTOCATALYTIC REACTIONS

Aaltonen, T., Kallatsa, O., Simell, J., Sneitz, N., Konn, J., Hiltunen, J. & Koskinen, A., 2019, IPC No. C07C 317/ 14 A I, Patent No. WO2019043289, 27 Aug 2018, Priority date 29 Aug 2017, Priority No. FI20170005768

Research output: Patent

Synthesis of the C1-C12 Fragment of Calyculin C

Konstantinova, O. V. & Koskinen, A. M. P., 1 Jan 2019, In : Synthesis (Germany). 51, 1, p. 285-295 11 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

File

107 Downloads (Pure)

Copper Catalyzed Alcohol Oxidation and Cleavage of β-O-4 Lignin Model Systems: From Development to Mechanistic Examination

Salonen, H. E. P., Mecke, C. P. A., Karjomaa, M. I., Joensuu, P. M. & Koskinen, A. M. P., 30 Nov 2018, In : ChemistrySelect. 3, 44, p. 12446-12454 9 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

File

2 Citations (Scopus)

27 Downloads (Pure)

Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

van Adrichem, A. J., Fagerholm, A., Turunen, L., Lehto, A., Saarela, J., Koskinen, A., Repasky, G. A. & Wennerberg, K., 2015, In : COMBINATORIAL CHEMISTRY AND HIGH THROUGHPUT SCREENING. 18, 1, p. 3-17

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

File