20002019

Research output per year

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Personal profile

Artistic and research interests

Professor Ari M.P.Koskinen was born on September 22, 1956 in Finland. He received his M.Sc. (Chem. Eng.) in 1979 (with professor T. Hase, development of the synthesis of alkyl tert-alkyl ethers for anti-knock agents), Licentiate in Technology in 1982 and Doctor of Technology in 1983 (with professor M. Lounasmaa, methodology development on the modified Polonovski reaction for indole alkaloid synthesis), all at the Helsinki University of Technology, Finland. After postdoctoral studies at the University of California, Berkeley (professor Henry Rapoport 1983-85 and 1987-88, total synthesis of anatoxin-a, and conformationally constrained peptidomimetics) he accepted an appointment as a Project Leader in New Drug Development at Orion Corporation – Fermion, Finland (1985-1987). His research group was among the first in Scandinavia to adopt computer aided drug design (QSAR and CoMFA) as well as computerized database handling protocols in new lead identification. Returning to the Academia, he joined the University of Surrey, England, as a lecturer in 1989. He was then appointed as Professor of Chemistry (especially Synthetic Organic Chemistry) at the University of Oulu, Finland in 1992, and transferred to his current position at the Helsinki University of Technology in August, 1999 as Professor of Organic Chemistry (the old Gustav Komppa chair). Prof. Koskinen is a member of the Finnish Academy of Sciences and Letters since 2003. He is the author or co-author of some 190 publications, ten patents and two books.

His research ointerests include the development of novel synthetic methods especially in the field of enantioselective synthesis. A long standing project has centered on the transfer chirality information to new stereocenters on the synthesized molecule utilizing only the existing chiral information in the starting material (internal asymetric induction). The starting materials are selected from readily available, renewable natural compounds (amino acids), and the target compounds are natural  products or their analoges with biological significance. Over the years, a number of alkaloids, sphingosine like compounds and imino sugars have been synthesized.

Supervision of post-doc researchers

I have supervised a total of 38 post doctoral researchers during my career as a professor (first at the University of Oulu, and since 2000 at TKK/Aalto). They are:

Bauer, Martin
Bauer, Udo
Chen, Jingshan
Cura, Peter
Edmonds, Michael
Gefflaut, Thierry
Ghiaci, Mehran
Harden, Grahame
Hatam, Mostafa
Kamel, M.S.
Karvinen, Esko
Krische, M.J.
Lajunen, Marja
Munoz, Luis
Nevalainen, Marta
Page, Patrick
Psiorz, Christian
Schwerdtfeger, Jörg
Xia, Zhi-Qiang
Castillo, Joel
Straub, Thomas
Helaja, Juho
Koivisto, Jari
Rajamäki, Suvi
Tois, Jan
Monfray, Jeremy
Stewart, Alan
Bassas, Oriol
Reux, Bastien
Habrant, Damien
Linden, Auri
Chiesa, Katja
Huy, Peter
Venkatesh, K.B.
Tsoukala, Anna
Venkatesh, K.B.
Rembiak, Andreas
Konstantinova, Olga

Education/Academic qualification

Doctor of Science (Technology)

Licentiate of Science (Technology)

Master of Science (Technology)

Keywords

  • Organic chemistry
  • Natural products
  • Asymmetric synthesis

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Research Output

PROCESS FOR THE PREPARATION OF ARYL SULFONYLPROPENENITRILES BY PHOTOCATALYTIC REAC­TIONS

Aaltonen, T., Kallatsa, O., Simell, J., Sneitz, N., Konn, J., Hiltunen, J. & Koskinen, A., 2019, IPC No. C07C 317/ 14 A I, Patent No. WO2019043289, 27 Aug 2018, Priority date 29 Aug 2017, Priority No. FI20170005768

Research output: Patent

  • Synthesis of the C1-C12 Fragment of Calyculin C

    Konstantinova, O. V. & Koskinen, A. M. P., 1 Jan 2019, In : Synthesis (Germany). 51, 1, p. 285-295 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
  • 107 Downloads (Pure)

    Copper Catalyzed Alcohol Oxidation and Cleavage of β-O-4 Lignin Model Systems: From Development to Mechanistic Examination

    Salonen, H. E. P., Mecke, C. P. A., Karjomaa, M. I., Joensuu, P. M. & Koskinen, A. M. P., 30 Nov 2018, In : ChemistrySelect. 3, 44, p. 12446-12454 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
  • 2 Citations (Scopus)
    27 Downloads (Pure)

    Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

    van Adrichem, A. J., Fagerholm, A., Turunen, L., Lehto, A., Saarela, J., Koskinen, A., Repasky, G. A. & Wennerberg, K., 2015, In : COMBINATORIAL CHEMISTRY AND HIGH THROUGHPUT SCREENING. 18, 1, p. 3-17

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
  • 3 Citations (Scopus)
    132 Downloads (Pure)

    Enantiospecific Gram Scale Synthesis of (S)-Eleagnine

    Lood, C. S., Nieger, M. & Koskinen, A. M. P., 2015, In : Tetrahedron. 71, 30, p. 5019-5024

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    7 Citations (Scopus)
    394 Downloads (Pure)

    Prizes

    Årets Lyskukkere University of Tromssa, Norway

    Ari Koskinen (Recipient), 2003

    Prize: Award or honor granted for a specific work

    DuPont European Research Award

    Ari Koskinen (Recipient), 2001

    Prize: Award or honor granted for academic career

    Fellow of the Royal Society of Chemistry

    Ari Koskinen (Recipient), 2016

    Prize: Award or honor granted for academic career

    Holger Erdtman Lecturer

    Ari Koskinen (Recipient), 2001

    Prize: Award or honor granted for academic career

    Nuffield Foundation Young Investigator Award

    Ari Koskinen (Recipient), 1990

    Prize: Award or honor granted for academic career

    Activities

    Adele Varnier

    Ari Koskinen (Host)
    7 May 20183 Aug 2018

    Activity: Hosting a visitor typesHosting a visitor

    Challenging organic synthesis inspired by nature

    Ari Koskinen (Speaker)
    13 Dec 201814 Dec 2018

    Activity: Talk or presentation typesPublic or invited talk

    Daniele Castagnolo

    Ari Koskinen (Examiner)
    23 May 2018

    Activity: Examination typesStatement of assessment of professorship

    Chiara Esposito

    Ari Koskinen (Host)
    1 Apr 201830 Aug 2018

    Activity: Hosting a visitor typesHosting a visitor

    Thomas Vandepitte

    Ari Koskinen (Host)
    9 Apr 201822 Jun 2018

    Activity: Hosting a visitor typesHosting a visitor