Centre of Excellence in Molecular Systems Immunology and Physiology Research Group, SyMMys

Organisational unit: Research area

Research outputs

  1. 2020
  2. Accepted/In press

    Learning spectrograms with convolutional spectral kernels

    Shen, Z., Heinonen, M. & Kaski, S., 2020, (Accepted/In press) The 23rd International Conference on Artificial Intelligence and Statistic. (Proceedings of Machine Learning Research).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

  3. 2019
  4. Published

    Data-driven multiscale modeling reveals the role of metabolic coupling for the spatio-temporal growth dynamics of yeast colonies

    Intosalmi, J., Scott, A. C., Hays, M., Flann, N., Yli-Harja, O., Lähdesmäki, H., Dudley, A. M. & Skupin, A., 19 Dec 2019, In : BMC Molecular and Cell Biology. 20, 1, 59.

    Research output: Contribution to journalArticle

  5. Published

    Early detection of peripheral blood cell signature in children developing β-cell autoimmunity at a young age

    Kallionpää, H., Somani, J., Tuomela, S., Ullah, U., De Albuquerque, R., Lönnberg, T., Komsi, E., Siljander, H., Honkanen, J., Härkönen, T. & 11 others, Peet, A., Tillmann, V., Chandra, V., Anagandula, M. K., Frisk, G., Otonkoski, T., Rasool, O., Lund, R., Lähdesmäki, H., Knip, M. & Lahesmaa, R., 1 Oct 2019, In : DIABETES. 68, 10, p. 2024-2034 11 p.

    Research output: Contribution to journalArticle

  6. Published

    Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease

    Konki, M., Malonzo, M., Karlsson, I. K., Lindgren, N., Ghimire, B., Smolander, J., Scheinin, N. M., Ollikainen, M., Laiho, A., Elo, L. L. & 7 others, Lonnberg, T., Roytta, M., Pedersen, N. L., Kaprio, J., Lahdesmaki, H., Rinne, J. O. & Lund, R. J., 2 Sep 2019, In : Clinical epigenetics. 11, 1, 12 p., 130.

    Research output: Contribution to journalArticle

  7. Published

    Bayesian metabolic flux analysis reveals intracellular flux couplings

    Heinonen, M., Osmala, M., Mannerström, H., Wallenius, J., Kaski, S., Rousu, J. & Lähdesmäki, H., 15 Jul 2019, In : Bioinformatics. 35, 14, p. i548-i557 btz315.

    Research output: Contribution to journalArticle

  8. Published

    An additive Gaussian process regression model for interpretable non-parametric analysis of longitudinal data

    Cheng, L., Ramchandran, S., Vatanen, T., Lietzén, N., Lahesmaa, R., Vehtari, A. & Lähdesmäki, H., 17 Apr 2019, In : Nature Communications. 10, 1, p. 1-11 11 p., 1798.

    Research output: Contribution to journalArticle

  9. Published

    Deep learning with differential Gaussian process flows

    Hegde, P., Heinonen, M., Lähdesmäki, H. & Kaski, S., Apr 2019, The 22nd International Conference on Artificial Intelligence and Statistic. Vol. 89. p. 1-15 16 p. (Proceedings of Machine Learning Research; vol. 89).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

  10. Published

    A Mathematical Model for Enhancer Activation Kinetics During Cell Differentiation

    Nousiainen, K., Intosalmi, J. & Lähdesmäki, H., 1 Jan 2019, Algorithms for Computational Biology - 6th International Conference, AlCoB 2019, Proceedings. Vega-Rodríguez, M. A., Holmes, I. & Martín-Vide, C. (eds.). p. 191-202 12 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11488 LNBI).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

  11. Accepted/In press

    ODE2VAE: Deep generative second order ODEs with Bayesian neural networks

    Yildiz, C., Heinonen, M. & Lähdesmäki, H., 2019, (Accepted/In press) NeurIPS.

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

  12. 2018
  13. Published

    Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life

    Vatanen, T., Plichta, D. R., Somani, J., Münch, P. C., Arthur, T. D., Hall, A. B., Rudolf, S., Oakeley, E. J., Ke, X., Young, R. A. & 18 others, Haiser, H. J., Kolde, R., Yassour, M., Luopajärvi, K., Siljander, H., Virtanen, S. M., Ilonen, J., Uibo, R., Tillmann, V., Mokurov, S., Dorshakova, N., Porter, J. A., McHardy, A. C., Lähdesmäki, H., Vlamakis, H., Huttenhower, C., Knip, M. & Xavier, R. J., 17 Dec 2018, In : Nature Microbiology.

    Research output: Contribution to journalArticle

  14. Published

    Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood

    Lietzén, N., Cheng, L., Moulder, R., Siljander, H., Laajala, E., Härkönen, T., Peet, A., Vehtari, A., Tillmann, V., Knip, M. & 2 others, Lähdesmäki, H. & Lahesmaa, R., 1 Dec 2018, In : Scientific Reports. 8, 1, p. 1-13 5883.

    Research output: Contribution to journalArticle

  15. Published

    snpEnrichR: analyzing co-localization of SNPs and their proxies in genomic regions

    Nousiainen, K., Kanduri, K., Ricaño-Ponce, I., Wijmenga, C., Lahesmaa, R., Kumar, V. & Lähdesmäki, H., 1 Dec 2018, In : Bioinformatics (Oxford, England). 34, 23, p. 4112-4114 3 p.

    Research output: Contribution to journalArticle

  16. Published

    The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

    Vatanen, T., Franzosa, E. A., Schwager, R., Tripathi, S., Arthur, T. D., Vehik, K., Lernmark, Å., Hagopian, W. A., Rewers, M. J., She, J. X. & 12 others, Toppari, J., Ziegler, A. G., Akolkar, B., Krischer, J. P., Stewart, C. J., Ajami, N. J., Petrosino, J. F., Gevers, D., Lähdesmäki, H., Vlamakis, H., Huttenhower, C. & Xavier, R. J., 25 Oct 2018, In : Nature. 562, 7728, p. 589-594 6 p.

    Research output: Contribution to journalLetter

  17. Published

    Temporal clustering analysis of endothelial cell gene expression following exposure to a conventional radiotherapy dose fraction using Gaussian process clustering

    Heinonen, M., Milliat, F., Benadjaoud, M. A., François, A., Buard, V., Tarlet, G., D'Alché-Buc, F. & Guipaud, O., 1 Oct 2018, In : PloS one. 13, 10, p. 1-31 e0204960.

    Research output: Contribution to journalArticle

  18. Published

    Learning with multiple pairwise kernels for drug bioactivity prediction

    Cichonska, A., Pahikkala, T., Szedmak, S., Julkunen, H., Airola, A., Heinonen, M., Aittokallio, T. & Rousu, J., 1 Jul 2018, In : Bioinformatics. 34, 13, p. i509-i518

    Research output: Contribution to journalArticle

  19. Published
  20. Published

    Flex ddG: Rosetta Ensemble-Based Estimation of Changes in Protein–Protein Binding Affinity upon Mutation

    Barlow, K., Conchuir, S., Thompson, S., Suresh, P., Lucas, J., Heinonen, M. & Kortemme, T., 31 May 2018, In : Journal of Physical Chemistry B. 122, 21, p. 5389-5399 11 p.

    Research output: Contribution to journalArticle

  21. Published

    Quantitative proteomic characterization and comparison of T helper 17 and induced regulatory T cells

    Mohammad, I., Nousiainen, K., Bhosale, S. D., Starskaia, I., Moulder, R., Rokka, A., Cheng, F., Mohanasundaram, P., Eriksson, J. E., Goodlett, D. R. & 2 others, Lähdesmäki, H. & Chen, Z., 31 May 2018, In : PLoS Biology. 16, 5, e2004194.

    Research output: Contribution to journalArticle

  22. Published

    Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3

    Schmidt, A., Marabita, F., Kiani, N. A., Gross, C. C., Johansson, H. J., Éliás, S., Rautio, S., Eriksson, M., Fernandes, S. J., Silberberg, G. & 8 others, Ullah, U., Bhatia, U., Lähdesmäki, H., Lehtiö, J., Gomez-Cabrero, D., Wiendl, H., Lahesmaa, R. & Tegnér, J., 7 May 2018, In : BMC Biology. 16, 1, p. 1-35 47.

    Research output: Contribution to journalArticle

  23. Published

    Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter

    Lund, R. J., Osmala, M., Malonzo, M., Lukkarinen, M., Leino, A., Salmi, J., Vuorikoski, S., Turunen, R., Vuorinen, T., Akdis, C. & 3 others, Lähdesmäki, H., Lahesmaa, R. & Jartti, T., 5 May 2018, In : Allergy. 73, 8, p. 1735-1740 6 p.

    Research output: Contribution to journalArticle

  24. Published
  25. Published

    Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells

    Ubaid Ullah, U., Andrabi, S. B. A., Tripathi, S. K., Dirasantha, O., Kanduri, K., Rautio, S., Gross, C. C., Lehtimäki, S., Bala, K., Tuomisto, J. & 7 others, Bhatia, U., Chakroborty, D., Elo, L. L., Lähdesmäki, H., Wiendl, H., Rasool, O. & Lahesmaa, R., 20 Feb 2018, In : Cell Reports. 22, 8, p. 2094-2106 13 p.

    Research output: Contribution to journalArticle

  26. Published

    Generative models for quantification of DNA modifications

    Äijö, T., Bonneau, R. & Lähdesmäki, H., 1 Jan 2018, Methods in Molecular Biology. p. 37-50 14 p. (Methods in Molecular Biology; vol. 1807).

    Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

  27. Published

    A Nonparametric Spatio-temporal SDE Model

    Yildiz, C., Heinonen, M. & Lähdesmäki, H., 2018, NIPS 2018 Spatiotemporal Workshop: 32nd Conference on Neural Information Processing Systems (NIPS 2018), Montréal, Canada. Neural Information Processing Systems Foundation, p. 1-5

    Research output: Chapter in Book/Report/Conference proceedingConference contributionProfessional

  28. Published

    Learning unknown ODE models with Gaussian processes

    Heinonen, M., Yildiz, C., Mannerström, H., Intosalmi, J. & Lähdesmäki, H., 2018, Proceedings of the 35th International Conference on Machine Learning, ICML 2018. Vol. 5. p. 3120-3132 13 p. (Proceedings of Machine Learning Research; vol. 80).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

  29. Published

    Variational zero-inflated Gaussian processes with sparse kernels

    Hegde, P., Heinonen, M. & Kaski, S., 2018, 34th Conference on Uncertainty in Artificial Intelligence 2018, UAI 2018. AUAI Press, Vol. 1. p. 361-371 148

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

  30. 2017
  31. Published

    A Mutually-Dependent Hadamard Kernel for Modelling Latent Variable Couplings

    Remes, S., Heinonen, M. & Kaski, S., Nov 2017, Proceedings of the 9th Asian Conference on Machine Learning. Zhang, M-L. & Noh, Y-K. (eds.). p. 455-470 16 p. (Proceedings of Machine Learning Research; vol. 77).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

  32. Published

    Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children

    Zhao, G., Vatanen, T., Droit, L., Park, A., Kostic, A. D., Poon, T. W., Vlamakis, H., Siljander, H., Härkönen, T., Hämäläinen, A. M. & 7 others, Peet, A., Tillmann, V., Ilonen, J., Wang, D., Knip, M., Xavier, R. J. & Virgin, H. W., 25 Jul 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. E6166-E6175

    Research output: Contribution to journalArticle

  33. Published

    Efficient statistical methods for detecting differential methylation

    Halla-aho, V. & Lähdesmäki, H., 22 Jul 2017.

    Research output: Contribution to conferencePaperScientific

  34. Published

    Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation

    Tripathi, S. K., Chen, Z., Larjo, A., Kanduri, K., Nousiainen, K., Äijo, T., Ricaño-Ponce, I., Hrdlickova, B., Tuomela, S., Laajala, E. & 5 others, Salo, V., Kumar, V., Wijmenga, C., Lähdesmäki, H. & Lahesmaa, R., 30 May 2017, In : Cell Reports. 19, 9, p. 1888-1901 14 p.

    Research output: Contribution to journalArticle

  35. Published

    RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells

    Lund, R. J., Rahkonen, N., Malonzo, M., Kauko, L., Emani, M. R., Kivinen, V., Närvä, E., Kemppainen, E., Laiho, A., Skottman, H. & 5 others, Hovatta, O., Rasool, O., Nykter, M., Lähdesmäki, H. & Lahesmaa, R., 9 May 2017, In : Stem Cell Reports. 8, 5, p. 1442-1454 13 p.

    Research output: Contribution to journalArticle

  36. Published

    High-throughput automated microfluidic sample preparation for accurate microbial genomics

    Kim, S., De Jonghe, J., Kulesa, A. B., Feldman, D., Vatanen, T., Bhattacharyya, R. P., Berdy, B., Gomez, J., Nolan, J., Epstein, S. & 1 others, Blainey, P. C., 27 Jan 2017, In : Nature Communications. 8, p. 1-10 13919.

    Research output: Contribution to journalArticle

  37. Published

    Acquired Somatic Mutations in T Cells in Patients with Aplastic Anemia and Hypoplastic Myelodysplastic Syndromes

    Lundgren, S., Keränen, M., Nousiainen, K., Eldfors, S., Hannula, S., Hannunen, T., Ellonen, P., Walldin, G., Clemente, M., Ebeling, F. & 5 others, Rajala, H., Maciejewski, J. P., Lähdesmäki, H., Hellstrom-Lindberg, E. & Mustjoki, S., 2017, In : BLOOD. 130, Suppl 1, p. 1169-1169 1 p.

    Research output: Contribution to journalArticle

  38. Published

    Non-Stationary Spectral Kernels

    Remes, S., Heinonen, M. & Kaski, S., 2017, Advances in Neural Information Processing Systems 30: Proceedings of NIPS2017. Curran Associates, Inc., p. 4645-4654 (Advances in Neural Information Processing Systems; vol. 30).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

  39. Published

    TET2 and 3 proteins control iNKT cell lineage specification and TCR mediated expansion

    Tsagaratou, A., Avalos, E. G., Rautio, S., Browne, J. S., Togher, S., Pastor, W., Rothenberg, E. V., Lahdesmaki, H. & Rao, A., 2017, In : JOURNAL OF IMMUNOLOGY. 198, 1, Supplement, p. 215.11

    Research output: Contribution to journalArticle

  40. Published

    TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells

    Tsagaratou, A., González-Avalos, E., Rautio, S., Scott-Browne, J. P., Togher, S., Pastor, W. A., Rothenberg, E. V., Chavez, L., Lähdesmäki, H. & Rao, A., 2017, In : NATURE IMMUNOLOGY. 18, 1, p. 45-53

    Research output: Contribution to journalArticle

  41. 2016
  42. Published

    Selected proceedings of Machine Learning in Systems Biology: MLSB 2016

    van Dijk, A. D. J., Lähdesmäki, H., de Ridder, D. & Rousu, J., 13 Dec 2016, In : BMC Bioinformatics. 17, Supplement 16, 2 p.

    Research output: Contribution to journalEditorial

  43. Published

    Selected proceedings of Machine Learning in Systems Biology: MLSB 2016

    van Dijk, A. D. J., Lähdesmäki, H., de Ridder, D. & Rousu, J., Dec 2016, In : BMC Bioinformatics. 17

    Research output: Contribution to journalSpecial issue

  44. Published

    A subpopulation model to analyze heterogeneous cell differentiation dynamics

    Chan, Y. H., Intosalmi, J., Rautio, S. & Lähdesmäki, H., 1 Nov 2016, In : Bioinformatics. 32, 21, p. 3306-3313 8 p.

    Research output: Contribution to journalArticle

  45. Published

    Mature Let-7 miRNAs fine tune expression of LIN28B in pluripotent human embryonic stem cells

    Rahkonen, N., Stubb, A., Malonzo, M., Edelman, S., Emani, M. R., Närvä, E., Lähdesmäki, H., Ruohola-Baker, H., Lahesmaa, R. & Lund, R., 1 Nov 2016, In : STEM CELL RESEARCH. 17, 3, p. 498-503 6 p.

    Research output: Contribution to journalArticle

  46. Published

    The effect of host genetics on the gut microbiome

    Bonder, M. J., Kurilshikov, A., Tigchelaar, E. F., Mujagic, Z., Imhann, F., Vila, A. V., Deelen, P., Vatanen, T., Schirmer, M., Smeekens, S. P. & 20 others, Zhernakova, D. V., Jankipersadsing, S. A., Jaeger, M., Oosting, M., Cenit, M. C., Masclee, A. A. M., Swertz, M. A., Li, Y., Kumar, V., Joosten, L., Harmsen, H., Weersma, R. K., Franke, L., Hofker, M. H., Xavier, R. J., Jonkers, D., Netea, M. G., Wijmenga, C., Fu, J. & Zhernakova, A., 1 Nov 2016, In : NATURE GENETICS. 48, 11, p. 1407-1412 6 p.

    Research output: Contribution to journalArticle

  47. Published

    LuxGLM: A probabilistic covariate model for quantification of DNA methylation modifications with complex experimental designs

    Äijö, T., Yue, X., Rao, A. & Lähdesmäki, H., 1 Sep 2016, In : Bioinformatics. 32, 17, p. i511-i519

    Research output: Contribution to journalArticle

  48. Published

    Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

    Sieberts, S. K., Zhu, F., García-García, J., Stahl, E., Pratap, A., Pandey, G., Pappas, D., Aguilar, D., Anton, B., Bonet, J. & 83 others, Eksi, R., Fornés, O., Guney, E., Li, H., Marín, M. A., Panwar, B., Planas-Iglesias, J., Poglayen, D., Cui, J., Falcao, A. O., Suver, C., Hoff, B., Balagurusamy, V. S. K., Dillenberger, D., Neto, E. C., Norman, T., Aittokallio, T., Ammad-Ud-Din, M., Azencott, C. A., Bellón, V., Boeva, V., Bunte, K., Chheda, H., Cheng, L., Corander, J., Dumontier, M., Goldenberg, A., Gopalacharyulu, P., Hajiloo, M., Hidru, D., Jaiswal, A., Kaski, S., Khalfaoui, B., Khan, S. A., Kramer, E. R., Marttinen, P., Mezlini, A. M., Molparia, B., Pirinen, M., Saarela, J., Samwald, M., Stoven, V., Tang, H., Tang, J., Torkamani, A., Vert, J. P., Wang, B., Wang, T., Wennerberg, K., Wineinger, N. E., Xiao, G., Xie, Y., Yeung, R., Zhan, X., Zhao, C., Greenberg, J., Kremer, J., Michaud, K., Barton, A., Coenen, M., Mariette, X., Miceli, C., Shadick, N., Weinblatt, M., De Vries, N., Tak, P. P., Gerlag, D., Huizinga, T. W. J., Kurreeman, F., Allaart, C. F., Louis Bridges, S., Criswell, L., Moreland, L., Klareskog, L., Saevarsdottir, S., Padyukov, L., Gregersen, P. K., Friend, S., Plenge, R., Stolovitzky, G., Oliva, B., Guan, Y. & Mangravite, L. M., 23 Aug 2016, In : Nature Communications. 7, p. 1-9 12460.

    Research output: Contribution to journalArticle

  49. Published

    Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease

    Vaughn, B. P., Vatanen, T., Allegretti, J. R., Bai, A., Xavier, R. J., Korzenik, J., Gevers, D., Ting, A., Robson, S. C. & Moss, A. C., 10 Aug 2016, In : INFLAMMATORY BOWEL DISEASES. 22, 9, p. 2182-2190 9 p.

    Research output: Contribution to journalArticle

  50. Published

    Dysbiosis, inflammation, and response to treatment: A longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease

    Shaw, K. A., Bertha, M., Hofmekler, T., Chopra, P., Vatanen, T., Srivatsa, A., Prince, J., Kumar, A., Sauer, C., Zwick, M. E. & 5 others, Satten, G. A., Kostic, A. D., Mulle, J. G., Xavier, R. J. & Kugathasan, S., 13 Jul 2016, In : GENOME MEDICINE. 8, 1, 75.

    Research output: Contribution to journalArticle

  51. Published

    Genome wide analysis of protein production load in Trichoderma reesei

    Pakula, T. M., Nygren, H., Barth, D., Heinonen, M., Castillo, S., Penttilä, M. & Arvas, M., 28 Jun 2016, In : Biotechnology for Biofuels. 9, 1, p. 1-26 132.

    Research output: Contribution to journalArticle

  52. Published

    Data-driven mechanistic analysis method to reveal dynamically evolving regulatory networks

    Intosalmi, J., Nousiainen, K., Ahlfors, H. & Lähdesmäki, H., 15 Jun 2016, In : Bioinformatics. 32, 12, p. 288-296

    Research output: Contribution to journalArticle

  53. Published

    Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

    Yassour, M., Vatanen, T., Siljander, H., Hämäläinen, A. M., Härkönen, T., Ryhänen, S. J., Franzosa, E. A., Vlamakis, H., Huttenhower, C., Gevers, D. & 3 others, Lander, E. S., Knip, M. & Xavier, R. J., 15 Jun 2016, In : SCIENCE TRANSLATIONAL MEDICINE. 8, 343, 343ra81.

    Research output: Contribution to journalArticle

  54. Published

    Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

    Vatanen, T., Kostic, A. D., D'Hennezel, E., Siljander, H., Franzosa, E. A., Yassour, M., Kolde, R., Vlamakis, H., Arthur, T. D., Hämäläinen, A. M. & 15 others, Peet, A., Tillmann, V., Uibo, R., Mokurov, S., Dorshakova, N., Ilonen, J., Virtanen, S. M., Szabo, S. J., Porter, J. A., Lähdesmäki, H., Huttenhower, C., Gevers, D., Cullen, T. W., Knip, M. & Xavier, R. J., 5 May 2016, In : CELL. 165, 4, p. 842-853 12 p.

    Research output: Contribution to journalArticle

  55. Published

    Comparative analysis of human and mouse transcriptomes of Th17 cell priming

    Tuomela, S., Rautio, S., Ahlfors, H., Oling, V., Salo, V., Ullah, U., Chen, Z., Hämälistö, S., Tripathi, S., Äijö, T. & 6 others, Rasool, O., Soueidan, H., Wessels, L., Stockinger, B., Lähdesmäki, H. & Lahesmaa, R., May 2016, In : SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 83, 5, p. 380-380 1 p.

    Research output: Contribution to journalMeeting Abstract

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